Technology

High-grade

Electrode Technology

Technology

Overview

NeuroOne is developing minimally invasive solutions for brain related disorders which include epilepsy, essential tremors, Parkinson’s disease, dystonia and other neurological conditions. Additionally, we are investigating the potential applications of our technology associated with artificial intelligence. Our operations are focused on the development and commercialization of cortical grids and strips for use in continuous electroencephalogram (cEEG), depth electrodes for use in stereoelectroencephalography (sEEG), ablation electrodes and electrodes capable of providing chronic stimulation. Our electrodes have a new thin film technology which may reduce patient complications during procedures, allow for minimally invasive placement, designed to provide better signal clarity in recording brain activity for diagnosis, and may improve patient outcomes.

Cortical Electrode Grid
ZIF Connector
Disposable Cable

The Challenges With Current Cortical Electrodes

The identification of problematic brain regions responsible for epileptic seizures utilizes cEEG  and sEEG to record the electrical activity of the brain and identify locations of irregular electrical activity for surgical planning and treatment. Current cortical electrodes used to diagnose and treat neurological conditions have some shortcomings which limit their widespread use.

  • We expect our electrodes will be able to be implanted using a minimally invasive procedure utilizing a burr hole rather than a full craniotomy which is typically required to implant the currently available technology
  • Some currently available cortical electrode material cause brain tissue inflammation1
  • Our electrodes have demonstrated low noise, high-fidelity recordings that were capable of distinguishing single neuron activity1
  • Our product will include disposable, sterile cables which will save time and costs related to cable management

After problematic regions are identified, surgical removal or ablation is then performed in the hopes of treating the root of a patient’s epilepsy. Unfortunately, due to limited resolution provided by current cortical electrodes, determining the problematic areas can be challenging and potentially impact the patient’s outcome.

Our Solution

In comparison to currently available technologies, we are currently developing our strip, grid and depth electrodes with the goal of reducing overall procedure times, reducing the invasiveness and risks of the procedure, improving the comfort of the patient, and improving the accuracy of diagnosis so the patient may have a better quality of life.

Why Our Electrodes Are Better
  • We expect our electrodes will be able to be implanted using a minimally invasive procedure utilizing a dime sized burr hole rather than a full craniotomy which is typically required to implant the currently available technology
  • Our innovative thin film cortical electrode material has demonstrated in pre-clinical evaluations to cause less inflammation than currently available electrodes1
  • Our technology is expected to have fewer tails, which can reduce the risk of infection and decrease procedure time
  • Includes disposable, sterile cables which will save time and costs related to cable management

References

  1. Bower R, et al. December 2017. Development of Polyimide electrodes for high-resolution intracranial EEG recordings. (Abst. 1.060) 2.062) American Epilepsy Society. Washington, D.C.