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NeuroOne Products Are Under Development • NeuroOne Medical Cortical Electrodes Are Pending 510(k) Clearance
Our New Electrode Technology

NeuroOne is developing minimally invasive solutions for brain related disorders which include epilepsy, essential tremors, Parkinson’s disease, dystonia and other neurological conditions. We are focused on the development and commercialization of cortical grids and strips for use in continuous electroencephalogram (cEEG), depth electrodes for use in stereoelectroencephalography (sEEG), ablation electrodes and electrodes capable of providing chronic stimulation.

 

Our electrodes have a new thin film technology which may reduce patient complications during procedures, allow for minimally invasive placement, are designed to provide better signal clarity in recording brain activity for diagnosis, and may reduce the cost of care while improvng patient outcomes.

The Challenges With Current Electrodes

The process to identify the problematic regions in the brain  responsible for epileptic seizures utilizes cEEG and sEEG to record the electrical activity of the brain. Once the recordings are obtained, the clinical team can identify  locations of irregular electrical activity for surgical planning and treatment.

 

After problematic regions are identified, surgical removal or ablation is then performed in the hopes of treating the root of a patient’s epilepsy. Unfortunately, due to limited resolution provided by current cortical electrodes, determining the problematic areas can be challenging and potentially impact the patient’s outcome.

 

Current cortical electrodes used in cEEG to diagnose and treat neurological conditions have some shortcomings which limit their widespread use.

NeuroOne's Electrode Solution

In comparison to currently available technologies, we are developing our strip, grid and depth electrodes with the goal of reducing overall procedure times, reducing the invasiveness and risks of the procedure, improving the comfort of the patient, and improving the accuracy of diagnosis so the patient may have a better quality of life.

Cortical Electrode

We expect our electrodes will be able to be implanted using a minimally invasive procedure utilizing a dime sized burr hole rather than a full craniotomy which is typically required to implant the currently available technology.

Our innovative thin film cortical electrode material has demonstrated in pre-clinical evaluations to cause less inflammation than currently available electrodes.

Cable Assembly

Our technology is expected to have fewer tails, which can reduce the risk of infection and decrease procedure time

 

Includes disposable, sterile cables which will save time and costs related to cable management

Why NeuroOne's Electrode Solution is Better

  • We expect our electrodes will be able to be implanted using a minimally invasive procedure utilizing a dime sized burr hole rather than a full craniotomy which is typically required to implant the currently available technology

  • Our innovative thin film cortical electrode material has demonstrated in pre-clinical evaluations to cause less inflammation than currently available electrodes1

  • Our technology is expected to have fewer tails, which can reduce the risk of infection and decrease procedure time

  • Includes disposable, sterile cables which will save time and costs related to cable management

1. Bower R, et al. December 2017. Development of Polyimide electrodes for high-resolution intracranial EEG recordings. (Abst. 1.060) 2.062) American Epilepsy Society. Washington, D.C

 
Publications and Posters

Multi-Resolution Intracranial EEG Rodent Recording System

Development of Polyimide Electrodes for High-Resolution Intracranial EEG Recordings

Intellectual Property

Wisconsin Alumni Research Foundation

Our patent estate consists of three issued U.S. patents licensed from The Wisconsin Alumni Research Foundation (WARF) covering a neural probe array and thin-film micro electrode array and method. The licensed issued patents expire between 2025 and 2030, subject to any patent extensions that may be available.

  • U.S. Patent No. 8,483,794 (Neural probe array)

  • U.S. Patent No. 8,386,007 (Thin-film micro electrode array and method)

  • U.S. Patent No. 7,774,053 (Method for implanting an electrode)

NeuroOne

NeuroOne converted two provisional patents to a patent application that was published on October 11, 2018 relating to a wide variety of concepts, ranging from accessories for brain surgery to ablation and stimulation concepts for both cortical and depth electrodes. We also recently filed a new provisional patent for the delivery of drugs using our electrodes.

  • Provisional Patent Filed on March 31, 2017

  • Provisional Patent Filed on October 26, 2017